E-Mail : info@incozen.com


The DMPK department has capabilities to support various drug discovery and drug development studies. Studies that INCOZEN routinely performs are as follows:

In vitro DMPK Services
  • Log P and Log D
  • Permeability (by PAMPA)
  • Metabolic stability in Liver microsomes /S9 fractions (Human, Mouse, Rat, Dog, Monkey)
  • Plasma Stability
  • Protein binding assay
  • CYP Inhibition assay (human liver microsomes)
In Vivo DMPK Services
  • All routes of administration (IP, IV, PO, SC etc.)
  • Pre-formulation development
  • Bioavailability studies
  • Single and multiple dose studies (Rat, Mice, Guinea Pig, Dog)
  • Excretion studies (urine, Feces)
  • Distribution studies
Bioanalytical Service
  • Method feasibility, development and validation across Biological Matrices
  • Analysis of preclinical pharmacokinetics and toxicokinetic (TK) studies
  • Analysis of Rodent / Non-Rodents and Human samples
  • Chemical Stability in relevant buffers and plasma
  • Solubility studies
  • Dose formulation analysis and validation